Hot off the press, studies from Australia have great great hope for BAricitinib. THis is a “medication” (anti-autoimmuneantibody) “drug” that aims to reverse early onset type 1 diabetes as well as I presume LADA.
What happens with type 1 diabetes is the body attacks itself and destroys the pancreas.
What happens with baricitinib is it stops that process.
This is really really great great news for anyone that is early in the process. And, we hope will point us in the right direction for somehow “reversing” damage in some cases. What is sad though is that fully blown type 1 is still likely a long way off being “cured” sadly.
But, this is hope and we are progressing faster than ever before.
Hope for a diabetes TYPE1 cure? It really does seem promising in the trial. But I guess what I want to say is the theory here, it all unfortunately with science (or fortunately) is a puzzle we have to retrospectively solve and then build a plan forward.
So : Golimumab is a biological anti TNF alpha, let’s just say if you have an “auto-immune process” going on- like ? type 1 diabetes -where the own body destroys one of it’s organs by itself. And you are attempting to figure this out and either at onset or pre-onset stop this from happening. Then the golimumab trial is really a great show that there is indeed an auto-immune process and thank fully that this can attempt to be reversed.
I still think that this is a complicated explanation. But this is rather complicated science.
Only I am grateful to golimumab and it’s other friends – we have a host of these “molecules” and trials. There are many many scientists, doctors behind the scenes in labs and on the ground working around the worldwide clocks to achieve progress.
What will it take to get people to sit up and listen and apply very simple steps to their lives to prevent type 2. What will it take to get governments to realise that uncontrolled diabetes is financially crippling as well as a complete disaster.
These things are preventable and treatable BEFORE we get to economic crumble – which is seemingly inevitable at the current pace. Not too sure if the politicians realise the implications, however far and wide it seems the people who choose politics don’t always have the general public’s best interest at heart.
Type 2 diabetes is essentially a lifestyle induced disease and yet uncontrolled the repercussions are : amputations, blindness, heart disease and kidney failure (dialysis). The cost implications of these aforementioned are HUGE as well as the loss of able body and minded people in the system of generating income.
Type 1 diabetes has exactly the same repercussions if not controlled and right from the get go is more expensive to manage properly. And yet with better management you ensure a healthy body that if targets are met will generally outlive the general public.
In south africa especially in the state sector both type 1 and 2 are poorly managed to say the very least and this knocks on to a growing population of patients requiring expensive treatments – that they inevitably get. It would make so much more sense to be preventative in terms of spending the money more wisely.
You don’t have to be a mathematician to understand what a log curve is. This is the current trajectory that we are on. With no sign of a slight dip of any relenting any time soon.
And yet – with simple interventions – like sugar tax and awareness we could really make a HUGE impact. Why ? Why are we not doing it? Is it because we do not WANT to??
Yes yes yes ! I am hoping (praying ) that Rizodeg will be scriptable by monday – you heard me this coming monday!
The insulin we have been waiting for : no stacking (NO stacking) nil to no hypos, steady release, long half life, a short acting component for meals -breakfast and supper – you can either eat NO carbs for lunch or do an extra short acting dose.
Essentially a BD – twice daily dose with far far better CONTROL – i.e. staying in the happy zone of 5-9 constantly – what joy!!!!
WE have been waiting and waiting for a product like this and it is about to arrive and arise!
Diabetics on insulin up to now have swung from high to low and low to high and had very little control over this, so many factors and “not at all predicable” absorption.
This new insulin solves many of our issues and we can not wait!!
Sadly probably not re-imbursed by med aids – but which diabetic would not gladly rather have quality of life?
Rather save on some other things and make sure the diabetic in your life has quality and quantity of life 🙂
So why do some patients go into honeymoon and some do not? It is a great mystery to me that I am hoping will also help us unravel the mystery of type 1 diabetes.
So type 1 diabetes is when your pancreas is NOT able to produce insulin. Is this problem, well yes. Every cell in the body requires glucose and the key molecule to take glucose into the cell is insulin. So without insulin cells literally die of starvation. The cell metabolism tries to use a desperate way to stay alive that is not sustainable and the eventual outcome is cell death.
What is it that causes one person to have a “honeymoon” period – i.e. easy to control diabetes either with diet or a combination of medication and diet and then all of a sudden the honeymoon is over?
Are we able to extend the honeymoon?
Are we able to figure out why some patients are diagnosed and never have a honeymoon?
These are answers I am after.
Type 1 diabetes is a real bugger of a disease. One you can never have a holiday from. One only a patient or a parent understands the devastation of.
WE have made leaps and bounds in type 2 diabetes, it is now time to make leaps and bounds in type 1.
Please contact me if you have any info/answers to my questions.
Late last year a serious miracle occurred and not too many people seem to be aware of this. A very brittle diabetic type 1 had a very successful trial.
She was insulin dependant with sugars all over the show from low to high to low again and then was placed on a new experimental “cure”. And, hold your breathe – it was successful and to my knowledge remains so!!!
The researchers found a way to place “islet cells” into her abdomen so that these “new” cells can produce the hormone insulin and she does not have to inject the life saving hormone any longer.
This is what we have been waiting for !! It is so very exciting that the technology is finally going to be able to progress to this point.
As I wipe the sleep dust from my eyes it is the end of the year. It feels like yesterday that I did the very same thing and it was January 2015. I am feeling that it is the end of the year in terms of that horrid fatigue and not much inspiration left kind of feeling. It has been a busy crazy jam packed year.
I have learnt a lot! I have grown and grown up. The year kicked off with some time out and joyous time spent with friends and family and very soon got into the hum drum of practice. Early in Feb (just after the horrid Charlie de Suis story) I have the great privilege of going to Paris for ATTD. It was especially special in that I got to spend time with my sister who lives in England. The people I met and interacted with were a wonderful blessing to me and it was certainly a highlight of my career thus far. I love diabetes for the people it has introduced me to as well as the amazing opportunities it has afforded me.
Life has happened as my husband would put it with the usual trials and tribulations including a broken arm and trip to the hospital with one of my littlies.
I had the extraordinary pleasure of a diabetic update in Capetown and was hugely treated to table mountain views, divine food and wine and company in August this year.
November opened itself with a super special opportunity to do cataract surgery at Zithulele – a great great joy. My littlies accompanied me and I can honestly say loved every second of the “missionary” life.
And here we are one week away from Christmas, how did we get here?
Blessed and precious times to all and may South africa go from strength to strength in 2016.
I was priveledged to attend a recent conference for diabetes care professionals in the broad – namely the entire team : biokineticists, dieticians, diabetic educators, podiatrists, ophthalmologists and doctors. Hope I didn’t leave anyone out. Unique in a sense and totally committed to the best care for diabetics at large in south africa.
I commend every speaker who was both entertaining and captivating and highly educative with messages that I am sure will stick in our minds with the sole purpose of improved and great medical care to our diabetics.
I guess the topic that most excites me is the prospect of closed loop technology in our time. Something that was very nicely detailed was the lack of any current insulin to “match” physiology and the much needed pattern of glucose uptake in order to enable euglycemia. Contrasted brilliantly (the best talk I have ever heard) by the journey towards efficacious/accurate closed loop techonology in our time.
Yes new insulins that better “match” glucose uptake will help, yes new drugs for type 2 diabetes are wonderful. However a “cure” for type 1 is yet another super super exciting prospect for type 1’s. The cost of this is definitely a limiting factor but the mind blowing research going into making this a concrete reality is exciting and something that any type 1 parent prays for.
The balance, with holisitic medicine not being ignored, covering science behind the benefits of coffee and cessation of smoking done masterfully.
There are many people in this country who work beyond the best of their ability. Many health professionals who attempt to steer the ship in the direction of safe, affordable yet excellent care and I commend these professionals who despite the tide that comes against them and the punches that are thrown never waiver in the task and as someone pointed out throw a tremendous counter punch ;).